刘振花

职称：副教授

联系电话：0371-23880680

E-mail：10200113@vip.henu.edu.cn

刘振花，博士，副教授，硕士生导师。

一、学习与工作经历：

1. 2011年获河南大学学士学位。

2. 2014年获中国科学院昆明植物研究所硕士学位。

3. 2017年获中国科学院昆明植物研究所博士学位。

4. 2017年至2023年5月，河南大学，药学院，讲师。

5. 2023年5月-至今，河南大学，开元体育,开元体育（中国），讲师。

二．主要的研究方向：

（1）天然产物活性成分研究：以活性为导向的天然产物分离、结构鉴定，涉及“谱效关系-敲出技术-高分辨质谱技术”快速发现复杂中药体系中的活性成分。

（2）药理活性研究：活性成分的抗糖尿病、凝血、抗炎、免疫等活性的研究。

三、主持的重要研究项目：

1. 主持国家自然科学基金青年基金：黄花败酱改善3T3-L1脂肪细胞胰岛素抵抗的活性成分及作用机制研究（31900292），2020.01-2022.12

2. 主持河南省科技发展计划项目：环烯醚萜类化合物改善胰岛素抵抗作用及机制研究（202102110149），2019.12-2021.12

3. 主持河南省科技发展计划项目：黄花败酱降血糖功能研究（192102110112），2019.01-2020.12

4. 主持开封市科技局项目：药食两用资源黄花败酱降血糖活性成分及作用机制研究（1908005），2018.07-2020.07

5. 参加国家重点研发食用菌资源开发和高效加工关键技术研究：食用菌资源开发和高效加工关键技术研究（2018YFD0400202），2019.01-2021.12

6. 参加国家自然科学基金面上项目：基于质谱分子网络从近缘亚属发现重楼药材可替代资源的评价研究（31770391），2018.01-2021.12

7. 参加河南省科技发展计划项目：金针菇功能食品的研发（182102110092），2018.01-2019.12

四、代表性研究论文(*为通讯作者)：

1. Meng-Jun Shi, Yi-Ping Cui, Cun-Yu Liu, Chang-Qin Li, Zhen-Hua Liu*, Wen-Yi Kang*. CYPs-mediated drug-drug interactions on psoralidin, isobavachalcone, neobavaisoflavone and daidzein in rats liver microsomes. Food and Chemical Toxicology, 2020, 136 (2020): 111027-111035. SCI Top 2区

2. Zhenhua Liu, Lanting Xu, Xiaoqing Xu, Yun Niu, FatmaS.A. Saadeldeen,Wenyi Kang∗.Effects and mechanisms of iridoid glycosides from Patrinia scabiosaefolia on improving insulin resistance in 3T3-L1 adipocytes. Food and Chemical Toxicology, 2019, 134, 110806. SCI Top 2区

3. Wen-Jing Li, Yan Zhang, Shu-Jin Shi, Gen Yang, Zhen-Hua Liu*, Jin-Mei Wang*, Wen-Yi Kang*. Spectrum-effect relationship of antioxidant and tyrosinase activity with Malus pumila flowers by UPLC-MS/MS and component knock-out method. Food and Chemical Toxicology, 2019, doi, 10.1016/j.fct.2019.110754. SCI Top 2区

4. Ying-Ying Niu, Jing-Dong, Hui-Min Jiang, Jin-Mei Wang, Zhen-Hua Liu*, Chang- Yang Ma, Wen-Yi Kang*. Effects of Polysaccharide from Malus halliana Koehne Flowers in Cyclophosphamide-Induced Immunosuppression and Oxidative Stress on Mice. Oxidative Medicine and Cellular Longevity. 2020, doi.org/10.1155/2020/1603735. SCI 2区

5. Chang-Qin Li, Yi-Ping Cui, Jie Lu, Cun-Yu Liu, Si-Tan Chen, Chang-Yang Ma, Zhen-Hua Liu*, Jin-Mei Wang*, Wen-Yi Kang*. Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum. Molecules, 2020, 25, doi:10.3390/molecules25061309. SCI 3区

6. Zhen-Hua Liu, Lan-Ting Xu, Mei-Mei Xing, Jin-Feng Wei, Jin-Mei Wang, Wen-Yi Kang. Trelagliptin succinate: DPP-4 inhibitor to improve insulin resistance in adipocytes. Biomedicine & Pharmacotherapy, 2020, 125（2020）109952. SCI 3区

7. Xu-Qiang Liu, Jing-Dong, Qiong-Xin Liang, Hui-Min David Wang, Zhen-Hua Liu*, Rui-An Xu* Wen-Yi Kang*. Coagulant Effectsand Mechanism of Schefflera heptaphylla (L.) Frodin. Molecules, 2019, 24, 24,4547-4559. SCI 3区

8. Meng-Jun Shi, Juan-Juan Zhang, Cun-Yu Liu, Yi-Ping Cui, Chang-Qin, Li, Zhen-Hua Liu*, Wen-Yi Kang*. Ionic Liquid-based ultrasonic-assisted extraction to analyze seven compounds in Psoralea Fructus coupled with HPLC. Molecules, 2019, 24(9), 1699-1713. SCI 3区

9. Xiao-Qing Xu, Fatma S. A. Saadeldeen, Lan-Ting Xu, Ying-Ying Zhao, Jin-Feng Wei, Hui-Min David Wang*, Zhen-Hua Liu*, Wen-Yi Kang*. The mechanism of phillyrin from the leaves of Forsythia suspensa for improving insulin resistance. BioMed Research International, 2019, doi, 10.1155/2019/3176483. SCI 3区

10. Li-Li Cui, Mi-Yun Hu, Peng-Ran Cao, Yun Niu, Chang-Qin Li, Zhen-Hua Liu*, Wen-Yi Kang*. Chemical constituents and coagulation activity of Syringa oblata Lindl flowers. BMC Chemistry, 2019, doi, 10.1186/s13065-019-0621-8. SCI 3区

11. Li-Li Cui, Xing-Zi Hou, Wen-Jing Li, Yu-Chun Leng, Yang Zhang, Xin-Juan Li, Zhen-Hua Liu*, Wen-Yi Kang*. Dynamic changes of secondary metabolites and tyrosinase activity of Malus pumila flowers. BMC Chemistry, 2019, doi, 10.1186/s13065-019-0602-y. SCI 3区

12. Zhen-Hua Liu, Bo Hou, Liu Yang, Rui-Jing Ma, Jin-Yu Li, Jiang-Miao Hu*, Jun Zhou*. Iridoids and Bis-iridoids from Patrinia scabiosaefolia. RSC Advances, 2017, 7: 24940-24949. SCI 3区

13. Zhen-Hua Liu, Rui-Jing Ma, Liu Yang, Jin-Yu Li, Jiang-Miao Hu, Jun Zhou. Triterpenoids and iridoids from Patrinia scabiosaefolia. Fitoterapia, 2017, 119: 130-135. SCI 3区

14. Zhen-Hua Liu, Huan Yan, Yong-Ai Si, Wei Ni, Yu Chen, Li He, Hai-Yang Liu*. Bioactive spirostane glycosides from Tacca plantaginea. Steroids, 2016, 106: 86-92. SCI 3区

15. Zhen-Hua Liu, Huan Yan, Yong-Ai Si, Wei Ni, Yu Chen, Chang-Xiang Chen, LiHe, Zhong-Quan Zhang, Hai-Yang Liu*. Plantagiolides K–N, three new withanolides and one withanolideglucoside from Tacca plantaginea. Fitoterapia. 2015, 105: 210-214. SCI 3区

16. Peng-Yu, Wang, Jian Li, Fatma Alzahra K. Attia, Wen-Yi Kang, Jin-Feng Wei, Zhen-Hua Liu*, Chang-Qin Li*. A critical review on chemical constituents and pharmacological effects of lilium. Food Science and Human Wellness, 2019, 8:330-336. SCI 4区

17. Zhen-Hua Liu, Huan Yan, Hai-Yang Liu*. Chemical constituents and bioactivities of plants of Taccaceae. Chemistry & Biodiversity. 2015, 12: 221-237. SCI 4区

五．奖励：

1. 康文艺，尹震花，王金梅，马常阳，张伟，姬利强，刘振花，张娟娟，李昌勤，魏金凤，李山雷，“谱效关系”结合“敲除技术”快速确定功效成分及功能产品开发，中国商业联合会科学技术奖，一等奖，2019